Biochemical and Biophysical Characterization study of promising hit: Molecular Modeling, Drug-design and Discovery Laboratory (MMDDL) and Pharmaceutical & Bioscience innovation Suite (PBIS), BCSIR Laboratories, Chittagong contemporary research interest and activities mainly in small molecule drug design, discovery, and development through integrated computational-experimental studies. Currently, we are working on experimental evidence-based database development of Bangladeshi medicinal plant-derived molecules for future nature inspired rational drug design and discovery. Apart from this, particularly we are focused on structure-based small molecule inhibitor design for kinases, bromodomain etc. for cancer and other diseases drug development. For the most promising candidate (hit) PBIS interested to characterize them with biochemical and biophysical profiling of protein-ligand interactions to support drug discovery programs for the first time in Bangladesh.

Lab Facilities

  • UV/Vis Absorbance
  • Fluorescence Intensity, including FRET
  • Fluorescence Polarization/Anisotropy
  • Time-Resolved Fluorescence, including TR-FRET
  • Alpha Screen┬« / Alpha LISA┬« / AlphaPlexTM
  • Luminescence (flash and glow), including BRET
  • Isothermal titration calorimeter
  • Bio-layer interferometry
  • Differential Scanning Calorymetry
  • -800C ultra low freezer
  • Biological safety Cabinet
  • Transgenic Rat and Mice
  • Rabbit and guneapig
  • Biochemistry Analyzer